Throat swab specimens were collected at admission, and the laboratory nucleic acid tests using real time polymerase chain reaction (RT-PCR) for COVID-19 RNA were conducted immediately in the Laboratory department of West Branch of Union hospital. All patients who were diagnosed with COVID-19 pneumonia according to WHO interim guidance were enrolled in the study. The COVID-19 patients’ clinical characteristics were retrospectively analyzed from January 29 to Februin the West Branch of Union Hospital in Wu Han province. We aim to explore risk factors of severe disease and in-hospital death for patients, and help clinicians to identify patients on admission with poor prognosis. In this study, we investigated the white blood cells (WBC) count of patients with confirmed COVID-19 and a definite clinical outcome (death or discharge) who were admitted to the West Branch of Union Hospital in Wuhan. However, the data on the clinical characteristics at the early stage and outcomes of patients with SARS-CoV-2 infection remain scarce. Older age with comorbidities, higher neutrophil-to-lymphocyte ratio, higher MuLBSTA score, higher Sequential Organ Failure Assessment (SOFA) score, and d-dimer greater than 1 μg/L on admission were associated with worse outcomes. At this stage, the mortality rate is high. Patients with severe illness may progress to shortness of breath, and might develop acute respiratory distress syndrome (ARDS), septic shock, and require intensive care unit (ICU) admission. No antiviral treatment for coronavirus infection has been proven to be effective. Ground-glass opacity (GGO), consolidation lesions, and reticular patterns were the common radiologic findings on chest computed tomography (CT). The most common symptoms are fever, dry cough, and fatigue. The pathogen has been identified as a novel enveloped RNA beta coronavirus that has currently been named severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2), which is sufficiently divergent from SARS-CoV. Since December 2019, coronavirus disease 2019 (COVID-19) emerged and rapidly spread throughout world. Higher level of WBC count should be given more attention in the treatment of COVID-19. WBC count at admission is significantly corelated with death in COVID-19 patients. In addition, Kaplan-meier survival analysis showed that there was a significant decline of the cumulative survival rate ( p < 0.001) in those with WBC count ≥6.16 × 10^9/L.
The difference was still exist after adjusting for confounding factors (HR = 6.26, 95%CI: 1.72–22.77, p = 0.005). ResultsĪ total of 163 patients including 33 death cases were included in this study. Demographic and clinical data including laboratory examinations were analyzed and compared between recovery and death patients. In this retrospective, single-center study, all confirmed patients with COVID-19 at West Branch of Union Hospital from Jan 29 to were collected and analyzed. White blood cells (WBC) count as a reflection of inflammation has played a vital role in COVID-19, however its level with death is not yet investigated. Its risk factors with death were still not known. Coronavirus disease-19 (COVID-19) has become a world health threaten.
0 kommentar(er)
